Tert-Butylamine → HCID 71279911, compound

Participants

Reaction Steps

2-(1-Methyl-1H-indazol-3-yl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxylic acid (120 mg, 0.41 mmol), tert-butylamine (0.1 mL, 0.9 mmol) and HATU (233 mg, 0.61 mmol) in 20 mL of dry THF was stirred for 4 hours. The reaction mixture was evaporated to dryness, 20 mL of 0.5N HCl were added to the residue, product extracted with ethyl acetate (3×50 mL), combined organics dried over sodium sulfate and concentrated. The residue was purified by column chromatography (silica gel, 200-300 mesh, eluting with ethyl acetate/petroleum ether=2:1) to give N-tert-butyl-2-(1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (47 mg, 33.7%). LCMS: (M+H)+=349; 1H NMR (300 MHz, DMSO): δ 12.75 (s, 1H), 9.07 (s, 1H), 8.48 (d, 1H, J=7.8 Hz), 8.35 (s, 1H), 7.96 (s, 1H), 7.5 (d, 1H, J=7.8 Hz), 7.49 (t, 1H, J=7.5 Hz), 7.27-7.22 (m, 1H), 4.17 (s, 3H), 1.52 (s, 9H).

Provenance & Evidence