Trifluoroacetic acid → HCID 71279311, compound

Participants

Reaction Steps

To a stirred mixture of tert-butyl 3-(2-(1,6-dimethyl-1H-indazol-3-yl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxamido)-3-methylpyrrolidine-1-carboxylate (130 mg, 0.266 mmol) in dichloromethane (2.5 mL) was added drop-wise trifluoroacetic acid (2 mL) at room temperature and the reaction mixture stirred for 2 hours. The mixture was diluted with aqueous NaHCO3, filtered, washed with water and dried to give 2-(1,6-dimethyl-1H-indazol-3-yl)-N-(3-methylpyrrolidin-3-yl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide (35 mg, 34%) as a pale solid.

Provenance & Evidence