Hydrochloric Acid → HCID 71280200, compound

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Reaction Steps

tert-Butyl (1-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)cyclopropyl)methylcarbamate (95 mg, 0.20 mmol) was dissolved in 20 mL of a saturated solution of HCl (g) in dioxane and the solution was stirred at room temperature for 3 hours. The solvent was evaporated at 40° C. under reduced pressure and the residue was triturated with ethyl acetate (10 mL) then decanted and dried to give N-(1-(aminomethyl)cyclopropyl)-2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide hydrochloride (13 mg, 15.8%) as a pale yellow solid. MS: (M+H)+=380.1; 1H NMR (300 MHz, CD3OD): δ 9.18 (s, 1H), 8.43-8.41 (m, 2H), 7.45 (d, 1H, J=9.3 Hz), 7.19 (s, 1H), 4.17 (s, 3H), 3.32 (s, 2H), 1.25 (s, 4H).

Provenance & Evidence