Water → 2-bromo-N-tert-butyl-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide

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Reaction Steps

To a stirred solution of 2-bromo-N-tert-butyl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide and (chloromethanetriyl)tribenzene (1.55 g, 5.56 mmol) in DMF (10 mL) was added triethylamine (0.56 g, 5.56 mmol). The mixture was stirred at room temperature for 16 hours. The mixture was poured into water and extracted with EtOAc (3×15 mL). The combined organic layers were washed with brine and dried over Na2SO4. After filtration and concentration, the residue was purified by column chromatography on silica gel eluting with petroleum ether/EtOAc (10:1) to give 2-bromo-N-tert-butyl-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide (1.1 g, 73%) as a pale yellow solid. 1H NMR (300 MHz, DMSO): δ 8.30 (s, 1H), 8.00 (s, 1H), 7.70 (s, 1H), 7.38-7.25 (m, 10H), 7.19-7.15 (m 5H), 1.27 (s, 9H).

Provenance & Evidence