Hydrochloric Acid → HCID 71280320, compound

Participants

Reaction Steps

To a stirred solution of N-tert-butyl-2-(1-methyl-1H-indazol-4-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide (154 mg, 0.261 mmol) in dioxane (20 mL) was bubbled HCl gas until saturation and then stirred at room temperature for 4 hours. Reaction mixture was concentrated and the residue was triturated with methanol (1 mL) then decanted and dried to afford N-tert-butyl-2-(1-methyl-1H-indazol-4-yl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide hydrochloride (38 mg, 38%) as a white solid. LCMS: (M+H)+=349; 1H NMR (300 MHz, CDCl3): δ 9.77 (s, 1H), 8.89 (s, 1H), 8.54 (s, 1H), 8.39 (s, 2H), 7.66-7.52 (m, 3H), 4.20 (s, 3H), 1.58 (s, 9H).

Provenance & Evidence