Hydrochloric Acid → HCID 71279493, compound

Participants

Reaction Steps

To a solution of 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate (120 mg, 0.24 mmol) in 10 mL of dioxane was bubbled HCl gas for 3 h. The reaction mixture was stirred overnight at room temperature. The formed precipitate was separated by filtration and the filter cake was washed with 10 mL of ether to give 30 mg of N-(5-amino-tetrahydro-2H-pyran-3-yl)-2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide hydrochloride. LCMS: (M+H)+=410.

Provenance & Evidence