2,6-Dimethoxy-4-(2-hydroxyethyl)benzeneboronic acid → N-(2,6-dichlorobenzoyl)-4-[2,6-dimethoxy-4-(2-hydroxyethyl)phenyl]-L-phenylalanine ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	2,6-Dimethoxy-4-(2-hydroxyethyl)benzeneboronic acid	HCID 54025269	—
Reactant	(S)-Ethyl 3-(4-bromophenyl)-2-(2,6-dichlorobenzamido)propanoate	HCID 54106344	—
Product	N-(2,6-dichlorobenzoyl)-4-[2,6-dimethoxy-4-(2-hydroxyethyl)phenyl]-L-phenylalanine ethyl ester	HCID 54075239	—

Reaction Steps

2,6-Dimethoxy-4-(2-hydroxyethyl)benzeneboronic acid was coupled with N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine ethyl ester according to the procedure described in Example 8-3) to yield 1.3 g of N-(2,6-dichlorobenzoyl)-4-[2,6-dimethoxy-4-(2-hydroxyethyl)phenyl]-L-phenylalanine ethyl ester. ESMS: m/z 546 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06855843B2
Source dataset	uspto-grants-2005_02
ORD ID	ord-8da01595314b4661810b4f23035bf727
Source note	uspto-grants-2005_02