1,3,5-Triazin-2-amine, 4-methoxy-6-(2,2,2-trifluoroethoxy)- → HCID 13726765, compound

HRID 246794Notes

Reaction equation

HRID 246794 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])[N:5]=[C:4]([O:14][CH3:15])[N:3]=1.[CH2:16]([O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25]([N:28]=[C:29]=[O:30])(=[O:27])=[O:26])[CH3:17]>C(Cl)Cl>[CH2:16]([O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25]([NH:28][C:29]([NH:1][C:2]1[N:3]=[C:4]([O:14][CH3:15])[N:5]=[C:6]([O:8][CH2:9][C:10]([F:11])([F:13])[F:12])[N:7]=1)=[O:30])(=[O:26])=[O:27])[CH3:17]

Participants

4

Reactant 2

HCID 1809581,3,5-Triazin-2-amine, 4-methoxy-6-(2,2,2-trifluoroethoxy)-HCID 13726764HCID 13726764, compound

Product 1

HCID 13726765HCID 13726765, compoundYield 76.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 1.9 g of 2-amino-4-(2,2,2-trifluoroethoxy)-6-methoxy-1,3,5-triazine suspended in 50 mL of dry methylene chloride was added 2.4 g of 2-ethoxybenzenesulfonyl isocyanate. The mixture was stirred at ambient temperature for three days, filtered, and the filtrate stripped to an oil which crystallized. The solid was triturated with n-butyl chloride and collected to give 2.94 g of white solid with m.p. 180°-181° (dec).

Workup

  1. filtrationfiltered
  2. customcrystallized
  3. customThe solid was triturated with n-butyl chloride
  4. customcollected

Sources & evidence

ORD record
ord-c76dc262b1c54c07b7000f042a560082
Source dataset
uspto-grants-1987_11
Patent number
US04704159

Reaction notes

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