HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → 7-(3-chloropropoxy)-2H-1,4-benzoxazin-3(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 7-hydroxy-3,4-dihydro-2H-1,4-benzoxazin-3-one | HCID 10057870 | — |
| Solvent | Glycol monoethyl ether | HCID 8076 | — |
| Product | 7-(3-chloropropoxy)-2H-1,4-benzoxazin-3(4H)-one | HCID 13343872 | 65% |
Reaction Steps
7-Hydroxy-2H-1,4-benzoxazin-3(4H)-one was treated with 3-bromo-1-chloro-propane and sodium metal in ethyleneglycol monoethyl ether to give the desired product in 65% yield, mp 95° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04704390 |
| Source dataset | uspto-grants-1987_11 |
| ORD ID | ord-4d4b354b4f8b435585fd534459a315f7 |
| Source note | uspto-grants-1987_11 |