2-Fluoro-4-formylbenzonitrile → HCID 178447930, compound

HRID 246873Notes

Reaction equation

HRID 246873 reaction equation
[C:1]([C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[O:8])=[CH:5][C:4]=1[F:11])#[N:2].[CH2:12]([C@H:15]1[CH2:20][CH2:19][C@H:18]([CH:21]([CH2:24]O)[CH2:22][OH:23])[CH2:17][CH2:16]1)[CH2:13][CH3:14]>>[C:1]([C:3]1[CH:10]=[CH:9][C:6]([CH:7]2[O:23][CH2:22][CH:21]([C@H:18]3[CH2:17][CH2:16][C@H:15]([CH2:12][CH2:13][CH3:14])[CH2:20][CH2:19]3)[CH2:24][O:8]2)=[CH:5][C:4]=1[F:11])#[N:2]

Participants

3

Reactant 2

HCID 112173392-Fluoro-4-formylbenzonitrileHCID 178447994HCID 178447994, compound

Product 1

HCID 178447930HCID 178447930, compound

Procedure

A mixture of 3.0 g of 4-cyano-3-fluorobenzaldehyde and 4.0 g of 2-(trans-4-n-propylcyclohexyl)-propane-1,3-diol is reacted analogously to Example 5. 2-(4-Cyano-3-fluorophenyl)-5-(trans-4-n-propylcyclohexyl)-1,3-dioxane is obtained. The following compounds are prepared analogously:

Workup

  1. customis reacted analogously to Example 5

Sources & evidence

ORD record
ord-ce3e684416804b589e81ff5418f0589a
Source dataset
uspto-grants-1987_11
Patent number
US04704227

Reaction notes

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