Ammonia → 4-Chlorophenylalanineamide

HRID 246886Notes

Reaction equation

HRID 246886 reaction equation
Cl.C[O:3][C:4](=O)[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)[NH2:6].[NH3:16]>CO>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][C@@H:5]([C:4]([NH2:16])=[O:3])[NH2:6])=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 236191574-Chloro-L-phenylalanine methyl ester hydrochloride

Product 1

HCID 186106874-Chlorophenylalanineamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.1 mole (25 grams) of 4-chlorophenylalanine methyl ester hydrochloride were dissolved in 250 ml of methanol. Then ammonia was led in at 0° C. several times, each time up to saturation. The reaction was finished after 4 days. The solvent was drawn off and the white residue dried. The product was employed in this form in the next step.

Workup

  1. customwas led in at 0° C. several times
  2. customthe white residue dried

Sources & evidence

ORD record
ord-9c28fdba59da485eaf02b8f384179fce
Source dataset
uspto-grants-1987_11
Patent number
US04704464

Reaction notes

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