HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dimethoxy-3-(hydroxymethyl)benzeneboronic acid → N-(2,6-dichlorobenzoyl)-4-[2,6-dimethoxy-3-(hydroxymethyl)phenyl]-L-phenylalanine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dimethoxy-3-(hydroxymethyl)benzeneboronic acid | HCID 22571818 | — |
| Reactant | (S)-Ethyl 3-(4-bromophenyl)-2-(2,6-dichlorobenzamido)propanoate | HCID 54106344 | — |
| Product | N-(2,6-dichlorobenzoyl)-4-[2,6-dimethoxy-3-(hydroxymethyl)phenyl]-L-phenylalanine ethyl ester | HCID 54057631 | — |
Reaction Steps
2,6-Dimethoxy-3-(hydroxymethyl)benzeneboronic acid was coupled with N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine ethyl ester in a similar method as described in Example 7-2) to give N-(2,6-dichlorobenzoyl)-4-[2,6-dimethoxy-3-(hydroxymethyl)phenyl]-L-phenylalanine ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06855843B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-7d54cf8a348c43769d85ac6070dedf22 |
| Source note | uspto-grants-2005_02 |