化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → Boc-Gln-Gln-Gly-OMe
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Ethylmorpholine | HCID 7525 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | L-Glutamine, N2-[(1,1-dimethylethoxy)carbonyl]-, 4-nitrophenyl ester | HCID 7017891 | — |
| 反応物 | HCID 178418300 | HCID 178418300 | — |
| 生成物 | Boc-Gln-Gln-Gly-OMe | HCID 131714598 | 82% |
反応手順
A solution of the residue obtained in the preceding step (theoretically 175.9 mM) in 500 ml of DMF, cooled on an ice bath, has 77.6 g of Boc-Gln-ONp (211.1 mM), 26.4 g of hydroxy benzotriazole (211.1 mM) and N-ethylmorpholine added thereto until a pH of 7 is obtained. After 20 hrs. of reaction at ambient temperature, the solution sets en masse. By addition of ethyl acetate, a precipitate is obtained which is drained, washed with AcOEt and dried in vacuo. 64.27 g of product are obtained, viz. a yield of 82%. Monitored by NMR and TLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04704450 |
| 出典データセット | uspto-grants-1987_11 |
| ORD ID | ord-839e1ab7a8194256b1fb8d7c2497aa41 |
| 出典メモ | uspto-grants-1987_11 |