HRID246924

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@@H](CO)C(=O)OCc1ccc([N+](=O)[O-])cc1

HCID11121352

未命名化合物

结构：N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(N)=O)C(=O)NCC(=O)O

HCID178512885

未命名化合物

PRODUCTS

生成物

结构：N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)O

HCID178512884

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID84468

Trifluoroacetate

C2F3O2-

PROCEDURE

实验过程

Likewise under the conditions of Example II-2 and from 806 g of H-Asn-Gln-Glu(OBzl)-Arg-Gly-OH and 366 g of Boc-Ser-ONb, the product is obtained, monitored by NMR and TLC with a yield of 688 g (77%) and in trifluoroacetate form.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4e0957acdcad4c10a10bf876809604d4
来源数据集: uspto-grants-1987_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04704450
来源说明: uspto-grants-1987_11

反应 SMILES

[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:16]([NH:18][C@H:19]([C:32]([NH:34][C@H:35]([C:43]([NH:45][CH2:46][C:47]([OH:49])=[O:48])=[O:44])[CH2:36][CH2:37][CH2:38][NH:39][C:40](=[NH:42])[NH2:41])=[O:33])[CH2:20][CH2:21][C:22](=[O:31])[O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:17])[CH2:11][CH2:12][C:13](=[O:15])[NH2:14])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5].CC(OC([NH:57][C@H:58]([C:61](OCC1C=CC([N+]([O-])=O)=CC=1)=[O:62])[CH2:59][OH:60])=O)(C)C>FC(F)(F)C([O-])=O>[NH2:57][C@H:58]([C:59]([NH:1][C@H:2]([C:7]([NH:9][C@H:10]([C:16]([NH:18][C@H:19]([C:32]([NH:34][C@H:35]([C:43]([NH:45][CH2:46][C:47]([OH:49])=[O:48])=[O:44])[CH2:36][CH2:37][CH2:38][NH:39][C:40](=[NH:41])[NH2:42])=[O:33])[CH2:20][CH2:21][C:22](=[O:31])[O:23][CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:17])[CH2:11][CH2:12][C:13](=[O:15])[NH2:14])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5])=[O:60])[CH2:61][OH:62]