Hydrochloric Acid → HCID 10494238, compound

Participants

Reaction Steps

A mixture of 4-amino-6,7-dihydro-6-(n-propyl)-1-vinylpyrazolo[3,4-b]pyrrolo[3,4-e]pyridin5-(1H)-one (9.9 g.) and acetonitrile (250 ml.) was stirred while 6N aqueous hydrochloric acid (100 ml.) was added. The mixture was heated under reflux for 3.5 hours under nitrogen. The cooled suspension was neutralized by the cautious addition of saturated aqueous sodium carbonate and the acetonitrile was removed at reduced pressure. The aqueous suspension of product was chilled to 4° overnight. The precipitated white solid was collected by filtration, washed with water, and dried in vacuo. There was thus obtained 8.0 g. of 4-amino-6,7-dihydro-1H-6-n-propylpyrazolo[3,4-b]pyrrolo[3,4-e]pyridin-5-(1H)-one. Recrystallization from acetonitrile gave a sample: m.p. 278°-281 °.

Provenance & Evidence