HCID 11658340, compound → HCID 20161345, compound

Participants

Reaction Conditions

Reaction Steps

2-Chloromethylsulfenyl-1-methylimidazole [see Preparation 10] (10 mmol) in DMF (12 ml) was added to a mixture of 5-chloropyrimidin-2-one hydrochloride (10 mmol) and potassium tert-butoxide (20 mmol) in DMF (72 ml). The mixture was stirred at 60° C. for 51/2 hours before the product was distilled off and the residue washed with water and ether. The product was oily. 1H HMR (DMSO d6, δ): 3.57 (CH3), 5.27 (--CH2 --), 6.95-7.22 (imidazole), 8.19 (H-4, d, j 4 Hz), 8.54 (H-6, d, J 4 Hz).

Provenance & Evidence