HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 6-[5-(4-Chlorobenzyl)-thien-2-yl]-hex-5-enoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (4-Carboxybutyl)triphenylphosphonium bromide | HCID 161236 | — |
| Reactant | 5-(4-Chlorobenzyl)thiophene-2-carbaldehyde | HCID 20161500 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-[5-(4-Chlorobenzyl)-thien-2-yl]-hex-5-enoic acid | HCID 54182590 | — |
Reaction Steps
This compound is prepared analogously to Example 7b from: 6.3 g of sodium hydride (=7.8 g of 80% strength mineral oil suspension) in 180 ml of dimethylsulphoxide, 57.9 g of 4-hydroxycarbonylbutyl-triphenylphosphonium bromide in 180 ml of dimethylsulphoxide and 25.0 g of 5-(4-chlorobenzyl)-thiophene-2-aldehyde in 20 ml of dimethylsulphoxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04705802 |
| Source dataset | uspto-grants-1987_11 |
| ORD ID | ord-37d47b237a01413e978b2383e470b0ce |
| Source note | uspto-grants-1987_11 |