Propylene Oxide → HCID 10802942, compound

HRID 247099Notes

Reaction equation

HRID 247099 reaction equation
[O:1]1[CH:3]([CH3:4])[CH2:2]1.[CH3:5][NH:6][CH2:7][CH2:8][CH:9]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CO>[CH3:5][N:6]([CH2:7][CH2:8][CH:9]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH2:2][CH:3]([OH:1])[CH3:4]

Participants

4

Reactant 2

HCID 6378Propylene Oxide2×HCID 119812N-Methyl-3,3-diphenylpropylamine

Product 1

HCID 10802942HCID 10802942, compoundYield 84.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6.38 g of 1,2-epoxypropane was added to a solution of 22.5 g of N-methyl-3,3-diphenylpropylamine in 60 ml of methanol. The solution was maintained at 15°-20° C. for 3 days, and then an additional 1.16 g of 1,2-epoxypropane was added. This solution was maintained for 24 hours at room temperature. The methanol was evaporated off and the product purified by chromatography on a silica gel column (methanol gradient in chloroform), to give 24 g of the title compound as colorless oil.

Workup

  1. temperatureThe solution was maintained at 15°-20° C. for 3 days
  2. customThe methanol was evaporated off
  3. customthe product purified by chromatography on a silica gel column (methanol gradient in chloroform)

Sources & evidence

ORD record
ord-a9e76a4324d44207aca420f9bf39c332
Source dataset
uspto-grants-1987_11
Patent number
US04705797

Reaction notes

Loading…