Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → HCID 135833470, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | 3-(3-Amino-1,2,4-oxadiazol-5-yl)-1-azabicyclo(2.2.1)heptane | HCID 163938 | — |
| 반응물 | Methyl 3-aminocrotonate | HCID 643918 | — |
| 생성물 | HCID 135833470 | HCID 135833470 | — |
반응 단계
A mixture of 500 mg of the oxadiazole intermediate prepared above, 240 mg of benzaldehyde and 260 mg of methyl 3-aminocrotonate in 5 ml of isopropyl alcohol was heated under reflux for 8 hours and then concentrated to dryness in vacuo. The residue was chromatographed on silica gel using chloroform-methanol (20:1, v/v) as eluent to give 600 mg of methyl 1,4-dihydro-2,6-dimethyl-3-(3-piperidinomethyl-1,2,4-oxadiazol-5-yl)-4-phenylpyridine-5-carboxylate as pale yellow crystals, mp. 187°-188° C. (decomp.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04705786 |
| 출처 데이터셋 | uspto-grants-1987_11 |
| ORD ID | ord-d10deda45e7046908272e8eba8a73574 |
| 출처 메모 | uspto-grants-1987_11 |