Hydrochloric Acid → HCID 135833463, compound

Participants

Reaction Steps

To a solution of 1.0 g of methyl 1,4-dihydro-6-dimethoxymethyl-3-[3-(N-benzyl-N-methylamino)methyl-1,2,4-oxadiazol-5-yl]-2-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate in 15 ml of acetone was added 2 ml of 6N-hydrochloric acid. After stirring at room temperature for 3 hours, the reaction mixture was neutralized with sodium bicarbonate solution and then concentrated in vacuo. To the residue was added ethyl acetate and the resultant solution was washed with water, dried and evaporated in vacuo. The residue was chromatographed on silica gel using chloroform-methanol (50:1) as eluent to give 740 mg of methyl 1,4-dihydro-3-[3-(N-benzyl-N-methylamino)methyl-1,2,4-oxadiazol-5-yl]-6-formyl-2-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate, IR νmaxneat cm-1 : 3350, 1700, 1680, 1640, 1600, 1520.

Provenance & Evidence