HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-((3-nitrophenyl)methylene)-3-oxobutanoate → SM 6586
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-((3-nitrophenyl)methylene)-3-oxobutanoate | HCID 1536427 | — |
| Reactant | Azane;hydrate | HCID 12896473 | — |
| Reactant | 5-acetonyl-3-(N-benzyl-N-methylamino)methyl-1,2,4-oxadiazole | HCID 20161256 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | SM 6586 | HCID 128443 | — |
Reaction Steps
A mixture of 250 mg of methyl 2-(3-nitrobenzylidene)acetoacetate, 260 mg of 5-acetonyl-3-(N-benzyl-N-methylamino)methyl-1,2,4-oxadiazole, 3 ml of isopropyl alcohol and 40 mg of 29% ammonia water was reacted and worked up as described in Example 104 to give methyl 1,4-dihydro-2,6-dimetyl-3-[3-(N-benzyl-N-methylamino)methyl-1,2,4-oxadiazol-5-yl]-4-(3-nitrophenyl)pyridine-5-carboxylate, m.p. 126°-127° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04705786 |
| Source dataset | uspto-grants-1987_11 |
| ORD ID | ord-2392f2e657514f2db6cbb02937a0862c |
| Source note | uspto-grants-1987_11 |