反应详情

A mixture of methyl 2,3,3a,4,7,7a-hexahydro-3a-hydroxy-5-methyl-7-(2-nitrophenyl)-1,1-dioxothieno[3,2-b]pyridine-6-carboxylate (2.5 g, 0.0065 moles) and toluene (60 mL) was refluxed for 24 hours. The solvent was removed in vacuo and the resulting solid was recrystallized from ethanol. The crystals were washed with diethyl ether 2× and dried at 65° C. under high vacuum for 48 hours. This gave 1.78 g product; mp 215°-217° C.

1. temperaturewas refluxed for 24 hours
2. customThe solvent was removed in vacuo
3. customthe resulting solid was recrystallized from ethanol
4. washThe crystals were washed with diethyl ether 2×
5. customdried at 65° C. under high vacuum for 48 hours