Thiophenol → HCID 20161746, compound

Participants

Reaction Steps

A mixture of thiophenol (9.09 g 0.0826 m), 2-methyl-2-(3-nitro-4-bromophenyl)propionitrile (18.68 g, 0.0694 m), sodium carbonate (16.0 g, 0.151 m) and absolute ethanol (300 ml) was stirred and heated at reflux for 5 hours. The cooled mixture was then poured onto ice-water and the resultant yellow solid filtered off. The crude solid was slurried with water/SVM (1.1, 300 ml) and the solid filtered and mixed with water/SVM (1:1, 150 ml. The solid was crystallised from methanol to give yellow needles (14.78 g, 65%) mpt. 146°-147° C. Calcd., for C16H14N2SO2 : C, 64.4 H, 4.7 N, 9.4; S, 10.7 Found: C, 64.5; H, 4.6; N, 9.3; S, 10.8

Provenance & Evidence