p-Chlorothiophenol → HCID 20161751, compound

Participants

Reaction Steps

A mixture of 4-chlorothiophenol (6.5 g, 0.045 m), 2-methyl-2-(3-nitro-4-bromophenyl)propionitrile (11.0 g, 0.041 m), sodium carbonate (8.67 g, 0.082 m) and absolute ethanol (150 ml) as stirred and heated at reflux for 4 hours. The mixture was cooled and poured into ice-water and the resultant yellow solid was filtered off. This solid was then slurried in a mixture of water and SVM (1:1, 150 ml) and refiltered and washed with water/SVM (1:1, 150 ml). The solid was crystallised from ethanol to give yellow crystals (11.86 g, 87%) mpt. 159°-160°.

Provenance & Evidence