化工社化工社 化学情報印刷レポート · 研究参考用
Kojic Acid → 5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Kojic Acid | HCID 3840 | — |
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | 5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one | HCID 901598 | — |
反応手順
To a stirred solution of 17 g (0.12 mole) of kojic acid and 5.1 g (0.13 mole) of sodium hydroxide in 190 ml of 10:1 (by volume) methanol-water was added dropwise 17.5 g (0.14 mole) of benzyl chloride. After 4.5 hours at reflux, the mixture was allowed to cool and was poured into 200 ml of ice-water. The resultant solid was collected, washed with water, and dried, giving 22.4 g of analytically pure title compound, m.p. 128°-130°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04705871 |
| 出典データセット | uspto-grants-1987_11 |
| ORD ID | ord-332fa967a5b1494198ad8a61e36c51af |
| 出典メモ | uspto-grants-1987_11 |