Sodium Hydroxide → 3-Fluorophenol

HRID 247187Notes

Reaction equation

HRID 247187 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:19]=[CH:18][CH:17]=[CH:16][C:5]=1[C:6]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=1)=[O:7]>CO>[F:3][C:4]1[CH:19]=[CH:18][CH:17]=[CH:16][C:5]=1[C:6]([OH:8])=[O:7].[F:15][C:11]1[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 13771073HCID 13771073, compound

Product 2

HCID 97433-FluorophenolYield 100%HCID 99352-Fluorobenzoic acidYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium hydroxide (0.109 g) was dissolved in 2 ml of methanol in a 10-ml Kjeldahl flask fitted with a reflux condenser, after which 0.234 g of m-fluorophenyl o-fluorobenzoate was added, and the mixture was heated under reflux for 60 minutes. After cooling, the experiment was operated as in Referential Example 4 to confirm that the reaction mixture contained 140 mg (yield 100%) of o-fluorobenzoic acid and 112 mg (yield 100%) of m-fluorophenol.

Workup

  1. customfitted with a reflux condenser
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 60 minutes
  4. temperatureAfter cooling

Sources & evidence

ORD record
ord-14bfb0aff1df4ce3ab75de603cdc87ad
Source dataset
uspto-grants-1987_11
Patent number
US04705884

Reaction notes

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