HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-Hydroxy-6-isoquinolinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 5-hydroxyisoquinoline-6-carboxylate | HCID 54242020 | — |
| Product | 5-Hydroxy-6-isoquinolinecarboxamide | HCID 18535986 | — |
Reaction Steps
5-Hydroxy-6-isoquinolinecarboxylic acid methyl ester as reported by Dyke, S. F. et al., in Tetrahedron 1973, 29(6), 857-62, is reacted with excess ammonia in a steel bomb for 12-18 hr. The excess ammonia is allowed to evaporate and the residue is crystallized from a suitable solvent mix such as ethyl acetate-toluene to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04705853 |
| Source dataset | uspto-grants-1987_11 |
| ORD ID | ord-5d402676aa1942e0ac660d4da313793b |
| Source note | uspto-grants-1987_11 |