Sodium Hydroxide → HCID 178433474, compound

HRID 247267Notes

Reaction equation

HRID 247267 reaction equation
[OH-].[Na+].[OH:3][C:4]1[N:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].[Cl:14][O-].[Na+]>O>[Cl:14][C:10]1[CH:9]=[C:5]([C:6]([OH:8])=[O:7])[C:4]([OH:3])=[N:12][C:11]=1[CH3:13]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 23665760Sodium HypochloriteHCID 178425908HCID 178425908, compound

Product 1

HCID 178433474HCID 178433474, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 15.7 g of 50% sodium hydroxide and 18.2 ml of water was added 10 g (0.065 mole) of 2-hydroxy-6-methylnicotinic acid. When the acid had dissolved, 200 ml of 5.25% aqueous sodium hypochlorite was added rapidly through a dropping funnel. The temperature was not moderated (slight exotherm did occur). The entire mixture was stirred at room temperature for 18 hr. The reaction mixture was then filtered and acidified with concentrated hydrochloric acid. The precipitate was recrystallized from isopropyl alcohol/ethereal to give ~6 g of analytically pure crystals, m.p. 291°-94° C.

Workup

  1. dissolutionWhen the acid had dissolved
  2. filtrationThe reaction mixture was then filtered
  3. customThe precipitate was recrystallized from isopropyl alcohol/ethereal
  4. customto give ~6 g of analytically pure crystals, m.p. 291°-94° C.

Sources & evidence

ORD record
ord-608af73f5b864975b54fddea2afedb6a
Source dataset
uspto-grants-1987_11
Patent number
US04705853

Reaction notes

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