HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 4-Cyclohexyl-2-[(dimethylamino)methyl]-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5(4H)-one oxalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | chloromethyl-4-cyclohexyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5(4H)-one | HCID 13729322 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-Cyclohexyl-2-[(dimethylamino)methyl]-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5(4H)-one oxalate | HCID 21271464 | — |
Reaction Steps
Utilizing the procedure of Example 10, 2-(chloromethyl)-4-cyclohexyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5(4H)-one (Intermediate 35) is reacted with 40% aqueous dimethylamine and reacted with oxalic acid in isopropyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04705853 |
| Source dataset | uspto-grants-1987_11 |
| ORD ID | ord-910853214471480a962fcfd08ba40da6 |
| Source note | uspto-grants-1987_11 |