HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 24736Generated: October 29, 2026
Hydrochloric Acid → HCID 178516549, compound
https://huagongshe.com/reaction/24736
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Oxindole | HCID 321710 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178516549 | HCID 178516549 | — |
Reaction Steps
26.6 g (0.2 mol) of 2-indolinone and 53.8 g (0.44 mol) of 4-dimethylamino-pyridine are dissolved in 400 ml of DMF and after the addition of 30.9 g (0.22 mol) of benzoylchloride in 100 ml of DMF stirred for 45 minutes at 45° C. The solution is poured onto 3 l of water and 100 ml of conc. hydrochloric acid, the precipitate formed is suction filtered, recrystallised from glacial acetic acid and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06855710B2 |
|---|
| Source dataset | uspto-grants-2005_02 |
|---|
| ORD ID | ord-a7f191f9f60f4495a13277724fab088b |
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| Source note | uspto-grants-2005_02 |
|---|
