Ammonia → HCID 70353925, compound

HRID 247367Notes

Reaction equation

HRID 247367 reaction equation
[O:1]=[C:2]1[NH:7][N:6]=[C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:20])[CH2:16][C:17]([CH3:19])=O)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[NH3:21]>>[O:1]=[C:2]1[NH:7][N:6]=[C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:20])/[CH:16]=[C:17](\[NH2:21])/[CH3:19])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 13646979Acetoacetic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3yl)-phenyl]-amide

Product 1

HCID 70353925HCID 70353925, compound

Procedure

12.5 g (45.7 mmoles) of acetoacetic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-phenyl]-amide in 225 ml of aqueous concentrated ammonia are heated under reflux for 2 hours. After cooling, the product if filtered off with suction and washed with water until it is neutral.

Workup

  1. temperatureunder reflux for 2 hours
  2. temperatureAfter cooling
  3. filtrationthe product if filtered off with suction
  4. washwashed with water until it

Sources & evidence

ORD record
ord-8dd03a2fab45419386cd13e428a915bf
Source dataset
uspto-grants-1987_11
Patent number
US04707479

Reaction notes

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