2-Pyridinemethanamine → HCID 178512370, compound

Participants

Reaction Steps

A mixture of 2-amino methyl pyridine (10.91 g) and 1-cyano-2-(3-tolyl)pseudourea (17.52 g) in 250 ml of isopropanol is stirred at reflux under a nitrogen atmosphere for 5 hours. The reaction mixture is allowed to cool to room temperature and the solvent is removed in vacuo. The dark green residual oil is stirred in 250 ml of diethyl ether. The resultant solid is collected and washed with ether, and ground to a paste in 100 ml of diethyl ether. The solid is filtered, washed with ether and dried in air. The solid is taken up in boiling acetone and filtered hot, concentrated in a hot plate and cooled. The precipitate is collected and recrystallized from acetone to yield 7.08 g of the cyano guanidine, MP 144° C.

Provenance & Evidence