Sodium borohydride → HCID 21276372, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.9 g (12.3 mmoles) of 4-formyl-N-(α-phenylethyl)phenoxazine, 250 ml of ethanol and 0.594 g (18.5 mmoles) of sodium borohydride was heated at 40° C. under stirring during 15 minutes. The solvent was then removed under reduced pressure and the residue diluted with water and extracted with ethyl acetate (2×100 ml). The combined extracts were dried and the solvent removed under reduced pressure. The oily residue (3.5 g) was percolated through a short column of silica gel using ether as the solvent, to yield 4-hydroxymethyl-N-(α-phenylethyl)phenoxazine, as an oil

Provenance & Evidence