6-(4-Ethoxy-3-methoxyphenyl)-3[2H]pyridazinone → 6-[4-(3-methylbutoxy)-3-methoxyphenyl]-3[2H]pyridazinone

HRID 247393Notes

Reaction equation

HRID 247393 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:8][C:7]=1[O:19][CH3:20])[CH2:2][CH2:3]C.[CH2:21]([O:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:31]=[CH:32][C:33](=[O:36])[NH:34][N:35]=2)=[CH:26][C:25]=1[O:37][CH3:38])[CH3:22]>>[CH:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:8][C:7]=1[O:19][CH3:20])([CH2:2][CH3:3])[CH3:21].[CH3:1][CH:2]([CH3:3])[CH2:22][CH2:21][O:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:31]=[CH:32][C:33](=[O:36])[NH:34][N:35]=2)=[CH:26][C:25]=1[O:37][CH3:38]

Participants

4

Reactant 2

HCID 201606276-(4-Ethoxy-3-methoxyphenyl)-3[2H]pyridazinoneHCID 201606496-(4-n-Butoxy-3-methoxyphenyl)-3[2H]pyridazinone

Product 2

HCID 201606336-[4-(3-methylbutoxy)-3-methoxyphenyl]-3[2H]pyridazinoneHCID 201606576-(4-sec.-butoxy-3-methoxyphenyl)-3[2H]pyridazinone

Procedure

In an analogous manner, 6-(4-n-butoxy-3-methoxyphenyl)-3[2H]pyridazinone, m.p. 193°; 6-(4-ethoxy-3-methoxyphenyl)- 3[2H]pyridazinone, m.p. 186°; 6-(4-sec.-butoxy-3-methoxyphenyl)-3[2H]pyridazinone, m.p. 168°, 6-[4-(3-methylbutoxy)-3-methoxyphenyl]-3[2H]pyridazinone, m.p. 170°, are obtained from the correspondingly substituted 3-benzoylacrylic acids.

Sources & evidence

ORD record
ord-af33ee00104445738ecc76818ebbd255
Source dataset
uspto-grants-1987_11
Patent number
US04707481

Reaction notes

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