反应详情

29.9 g of 6-(3-methoxy-4-n-propoxyphenyl)-3[2H]pyridazinone are introduced in portions into 65 ml of phosphorus oxide-trichloride, with stirring, and the mixture is then stirred at 100° for 1 hour. The reaction mixture is concentrated to half in vacuo and poured onto ice, with thorough stirring. The crystals which deposit are filtered off with suction, washed with water and dried in vacuo. 31.6 g of 3-chloro-6-(3-methoxy-4-n-propoxyphenyl)pyridazine are obtained.

1. stirringthe mixture is then stirred at 100° for 1 hour
2. concentrationThe reaction mixture is concentrated to half in vacuo
3. additionpoured onto ice, with thorough stirring
4. filtrationThe crystals which deposit are filtered off with suction
5. washwashed with water
6. customdried in vacuo