HCID 10220820, compound → HCID 20160634, compound

HRID 247396Notes

Reaction equation

HRID 247396 reaction equation
[CH2:1](OC1C=CC(C2C=CC(=O)NN=2)=CC=1OC)C(C)C.[CH2:21]([O:25][C:26]1[CH:27]=[C:28]([C:34]2[CH:35]=[CH:36][C:37](=[O:40])[NH:38][N:39]=2)[CH:29]=[CH:30][C:31]=1[O:32][CH3:33])[CH:22](C)C.C(OC1C=C(C2C=CC(=O)NN=2)C=CC=1OC)C.COC1C=C(C2C=CC(=O)NN=2)C=CC=1OCCC>>[CH:21]([O:25][C:26]1[CH:27]=[C:28]([C:34]2[CH:35]=[CH:36][C:37](=[O:40])[NH:38][N:39]=2)[CH:29]=[CH:30][C:31]=1[O:32][CH3:33])([CH3:22])[CH3:1]

Participants

5

Reactant 4

HCID 10220820HCID 10220820, compoundHCID 20160625HCID 20160625, compoundHCID 201606286-(3-isobutoxy-4-methoxyphenyl)-3[2H]pyridazinoneHCID 201606486-(3-ethoxy-4-methoxyphenyl)-3[2H]pyridazinone

Product 1

HCID 20160634HCID 20160634, compound

Procedure

The following are obtained analogously: 6-(4-isobutoxy-3-methoxyphenyl)-3[2H ]pyridazinone, m.p. 184°, 42.2% of theory, 6-(3-isobutoxy-4-methoxyphenyl)-3[2H]pyridazinone, m.p. 186°, 58.4% of theory, 6-(3-ethoxy-4-methoxyphenyl )-3[2H]pyridazinone, m.p. 171°, 73.1% of theory and 6-(3-methoxy-4-n-propoxyphenyl)-3[2H ]pyridazinone, m.p. 173°, 66.3% of theory.

Workup

  1. customThe following are obtained analogously

Sources & evidence

ORD record
ord-cc3d0fd824df4cd982e99679d5f47ad0
Source dataset
uspto-grants-1987_11
Patent number
US04707481

Reaction notes

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