Ethanol → 3-(1-Ethoxy-1-phenyl-methylidene)-2-indolinone

HRID 24740Notes

Reaction equation

HRID 24740 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13]([O:20][CH2:21][CH3:22])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:23])(=O)C.C(O)C.[OH-].[Na+]>O>[CH2:21]([O:20][C:13](=[C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:4][C:5]1=[O:23])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[CH3:22]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 542378881-Acetyl-3-(1-ethoxy-1-phenylmethylidene}-2-indolinone

Product 1

HCID 540376233-(1-Ethoxy-1-phenyl-methylidene)-2-indolinone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6.15 g (20 mmol) of 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone are suspended in a little ethanol. 10 ml of 4N sodium hydroxide solution are added and the mixture is stirred for 1.5 hours at ambient temperature. After the addition of 100 ml of water the precipitate is suction filtered, washed with water and a little ether and dried at 80° C.

Workup

  1. filtrationfiltered
  2. washwashed with water
  3. dry with materiala little ether and dried at 80° C.

Sources & evidence

ORD record
ord-2873a7ec518c40c286dc86ec59daace2
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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