HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(3,5-Difluorophenyl)acrylic acid → 3-(3,5-Difluorophenyl)propionic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(3,5-Difluorophenyl)acrylic acid | HCID 522810 | — |
| Edukt | HCID 178418361 | HCID 178418361 | — |
| Katalysator | Palladium | HCID 23938 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 3-(3,5-Difluorophenyl)propionic acid | HCID 3669498 | 99% |
Reaktionsschritte
A solution of 3-(3,5-difluorophenyl)propenoic acid (0.0435 mol) in tetrahydrofuran (100 ml) and a slurry of 10% palladium on carbon (1.5 g) in ethyl acetate were shaken together under 50 psi hydrogen for 4 hours. The mixture was filtered and concentrated to yield 8 g (99%) of a yellow oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04707488 |
| Quelldatensatz | uspto-grants-1987_11 |
| ORD ID | ord-d9ae1a7a367840edaf522e00b5698f79 |
| Quellennotiz | uspto-grants-1987_11 |