Bromine → 7-Bromo-2,3,4,5-tetrahydro-8-methoxy-1-phenyl-1H-3-benzazepine

Participants

Reaction Steps

8-Methoxy-1-phenyl-2,3,4,5-tetrahydro-1H3-benzazepine hydrochloride (66 g, 0.23 m) was suspended in acetic acid (300 ml) and treated with bromine (43 g, 0.27 m). The mixture was heated to 95° for one hour, cooled and filtered. The filter cake was partitioned between ethyl acetate and ammonium hydroxide to afford 7-bromo-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

Provenance & Evidence