Chloride → HCID 14151508, compound

Participants

Reaction Conditions

Reaction Steps

8-Methoxy-3-methyl-1-phenyl-7-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (4.5 g, 0.011 m) dissolved in methanesulfonic acid (165 ml) was treated with methionine (8.3 g, 0.055 m) and stirred for 16 hours at 25° C. The mixture was poured into ice water, basified with ammonium hydroxide and extracted with ethyl acetate. The organic phase was concentrated in vacuo and the residue purified by chromatography on silica eluted with methanol-methylene chloride (1:50) to give 8-hydroxy-3-methyl-1-phenyl-7-phenylthio-2,3,4,5-tetrahydro-1H-3-benzepine which was treated with hydrooen chloride to give 8-hydroxy-3-methyl-1-phenyl-7-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride, m.p. 175° C.

Provenance & Evidence