Chlorosulfonic acid → HCID 20160685, compound

Participants

Reaction Steps

A solution of 3-acetyl-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (13 g, 0.01 m) in methylene chloride (50 ml) stirred at 5° was treated with chlorosulfonic acid (11.6 g, 0.1 m). The mixture was stirred at 25° for 2 hours, poured into ice water and extracted with chloroform. The chloroform extract was washed, dried with sodium sulfate and concentrated in vacuo to give 3-acetyl-7-chlorosulfonyl-1-[4-(chlorosulfonyl)phenyl]-8-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine.

Provenance & Evidence