HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(3-Methoxy-4-bromophenyl)ethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Borane | HCID 6331 | — |
| Reactant | 2-(4-Bromo-3-methoxyphenyl)acetonitrile | HCID 2735584 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(3-Methoxy-4-bromophenyl)ethylamine | HCID 20160693 | — |
Reaction Steps
4-Bromo-3-methoxyphenylacetonitrile (22.6 g, 0.1 m) dissolved in tetrahydrofuran (100 ml) is added to 1M borane in tetrahydrofuran (300 ml) stirred at 25°. The mixture is refluxed, cooled to 0° and treated cautiously with 2N hydrochloric acid to give 4-bromo-3-methoxyphenethylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04707483 |
| Source dataset | uspto-grants-1987_11 |
| ORD ID | ord-47e39658919e4dcdb802753ce2c7d5af |
| Source note | uspto-grants-1987_11 |