Hydrochloric Acid → HCID 20160887, compound

Participants

Reaction Steps

An amount of 4 g of 6-methoxy-2-tetralone is reacted at 35° C. for 3 hours with 3.2 g of 2-amino-1-phenylethanol in 100 ml of methanol and 4 ml of glacial acetic acid in the presence of hydrogen and 0.3 g of platinum bioxide. After filtration and concentration, the residue is taken up with sodium hydroxide and extracted with ethyl acetate. The solution is dried over anhydrous sodium sulfate and evaporated. The black oil thus obtained is purified by flash-chromatography by utilizing a mixture of methylene chloride/methanol 9/1 as eluant. The fractions containing the product are collected and evaporated to dryness. The residue is dissolved in 20 ml of isopropyl alcohol and to the solution thus obtained there is added a saturated solution of hydrogen chloride in isopropyl alcohol. Thus, there is obtained the 2-[(6-methoxy-1,2,3,4-tetrahydronaphth-2-yl)amino]-1-phenylethanol hydrochloride, designated by its code number SR 58280 A, which, after crystallization from isopropyl alcohol, melts at 174°-176° C. Yield: 47.5% of the theoretical value.

Provenance & Evidence