Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | D-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, monohydrate | HCID 2724763 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 7038767 | HCID 7038767 | — |
Reaction Steps
25 g of Boc-D-Leu-OH.H2O was dissolved in 200 ml of THF. The solution was cooled to -20° C. 11 ml of N-methylmorpholine and 9.56 ml of ethyl chlorocarbonate were added to the solution. After 5 min, 12.9 g of a 70% aqueous ethylamine solution was added thereto and the mixture was stirred at about -5° C. for 2 h. After concentration, the residue was dissolved in ethyl acetate and washed with an aqueous NaHCO3 solution and water successively. After concentration to dryness, 24.5 g of Boc-D-Leu-NHC2H5 was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04707468 |
|---|
| Source dataset | uspto-grants-1987_11 |
|---|
| ORD ID | ord-de080da5d0764931831bd1dba3bd98c8 |
|---|
| Source note | uspto-grants-1987_11 |
|---|
