HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Acetate → 11-Deoxycortisol 21-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | 21-Chloro-17-hydroxy-4-pregnene-3,20-dione | HCID 10133413 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 11-Deoxycortisol 21-acetate | HCID 101816 | 88.3% |
Reaction Steps
1.0 g of 21-chloro-17-hydroxy-4-pregnene-3,20-dione in 20 ml of dimethylformamide is agitated at 80° C. with 1.0 g of potassium acetate. After 30 minutes, the reaction mixture is introduced into ice water, the precipitated product is suctioned off, dissolved in ethyl acetate, and dried over sodium sulfate, thus obtaining 940 mg of 21-acetoxy-17-hydroxy-4-pregnene-3,20-dione; mp 236.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04708823 |
| Source dataset | uspto-grants-1987_11 |
| ORD ID | ord-5718a5f9c8364edbb272e7673b5c4946 |
| Source note | uspto-grants-1987_11 |