Pyridine → HCID 13671602, compound

Participants

Reaction Steps

A solution of N-(1,2,2,2-tetrachloroethyl) salicylamide (30 g) in toluene (100 ml) is added dropwise at less than 10° C. to a solution of 2,2,2-trifluoroethanol (10 g) and pyridine (18.6 g) in toluene (150 ml). After the addition, the mixture is stirred at room temperature for a while, and the contents are washed with water and a 1% aqueous solution of sodium hydrogen carbonate. The toluene layer is dehydrated, and the toluene is evaporated under reduced pressure to give the desired N-[2,2,2,-trichloro-1-(2,2,2,-trifluoroethoxy) ethyl]-salicylamide (26 g) represented by the foregoing formula as a colorless viscous mass. This compound gradually solidifies and shows a melting point of 78° to 82° C.

Provenance & Evidence