Sodium Imidazole → HCID 70418100, compound

HRID 247546Notes

Reaction equation

HRID 247546 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]([CH3:14])[C:12](=[O:15])[N:11]([CH3:16])[C:10](=[N:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:9]=2)=[CH:4][CH:3]=1.[N-:24]1[CH:28]=[CH:27][N:26]=[CH:25]1.[Na+]>CS(C)=O>[NH:24]1[CH:28]=[CH:27][N:26]=[C:25]1[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]([CH3:14])[C:12](=[O:15])[N:11]([CH3:16])[C:10](=[N:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4605971Sodium ImidazoleHCID 18610809HCID 18610809, compound

Product 1

HCID 70418100HCID 70418100, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The invention encompasses compounds of Formula I which are prepared by arylating a starting material such as 3,4-dihydro-6-(4-fluorophenyl)-1,3,dimethyl-4-phenylimino-2(1H)-pyrimidinone with excess sodium imidazolide in DMSO in the presence of heat, whereby the fluoro group on the 6-phenyl ring is substituted by the imidazolyl group to produce 3,4-dihydro-6-(4-imidazolylphenyl)-1,3-dimethyl-4-phenylimino-2(1H)-pyrimidinone.

Workup

  1. customare prepared
  2. temperatureof heat

Sources & evidence

ORD record
ord-9a6b7be28f1a4747bde12ffddf4f38f5
Source dataset
uspto-grants-1987_11
Patent number
US04708958

Reaction notes

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