HCID 20159919, compound → N-(2-Amino-1-methylethyl)-5-isoquinolinesulfonamide

HRID 247578Notes

Reaction equation

HRID 247578 reaction equation
C(OC([NH:11][CH2:12][CH:13]([NH:15][S:16]([C:19]1[C:20]2[CH:21]=[CH:22][N:23]=[CH:24][C:25]=2[CH:26]=[CH:27][CH:28]=1)(=[O:18])=[O:17])[CH3:14])=O)C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[NH2:11][CH2:12][CH:13]([NH:15][S:16]([C:19]1[C:20]2[CH:21]=[CH:22][N:23]=[CH:24][C:25]=2[CH:26]=[CH:27][CH:28]=1)(=[O:18])=[O:17])[CH3:14]

Participants

5

Reactant 2

HCID 20159919HCID 20159919, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20159881N-(2-Amino-1-methylethyl)-5-isoquinolinesulfonamideYield 98%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

In 50 ml of ethanol was dissolved 2.0 g of N-(2-benzyloxycarbonylamino-1-methylethyl)-5-isoquinolinesulfonamide obtained above, and to the solution was added 0.1 g of 5% palladium-carbon. Then the solution was stirred at a temperature of 15° C.~25° C. in a hydrogen (0.7 to 1.40 kg/cm2) for 3 hours. The palladium-carbon was separated from the reaction solution by filtration under the reduced pressure. After the methanol was distilled therefrom, the reaction solution was concentrated to dryness to give 1.30 g of N-(2-amino-1-methylethyl)-5-isoquinolinesulfonamide in a yield of 98%.

Workup

  1. customobtained above, and to the solution
  2. customThe palladium-carbon was separated from the reaction solution by filtration under the reduced pressure
  3. distillationAfter the methanol was distilled
  4. concentrationthe reaction solution was concentrated to dryness

Sources & evidence

ORD record
ord-2a9cc801bfe4470eace18df7f1ffd9a2
Source dataset
uspto-grants-1987_11
Patent number
US04709032

Reaction notes

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