Water → HCID 178474254, compound

HRID 24761Notes

Reaction equation

HRID 24761 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]/[C:9](=[C:16]2\[C:17](=[O:25])[NH:18][C:19]3[C:24]\2=[CH:23][CH:22]=[CH:21][CH:20]=3)/[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[C:26](OC(=O)C)(=[O:28])[CH3:27].O>C(O)(=O)C>[C:26]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]/[C:9](=[C:16]2\[C:17](=[O:25])[NH:18][C:19]3[C:24]\2=[CH:23][CH:22]=[CH:21][CH:20]=3)/[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1)(=[O:28])[CH3:27]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 178507732HCID 178507732, compound

Product 1

HCID 178474254HCID 178474254, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

196 mg (0.6 mmol) of (Z)-3-[1-(4-aminophenylamino)-1-phenyl-methylidene]-2-indolinone are dissolved in 5 ml of glacial acetic acid and after the addition of 0.1 g (1 mmol) of acetic anhydride stirred for 3 hours at ambient temperature. Then 15 ml of water are added, the product precipitated is suction filtered, washed with water and dried.

Workup

  1. customthe product precipitated
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-1966048a0f8e41d49c2e9c11d16ae362
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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