反应详情

This compound is prepared by the procedure of Example 1 from 2.40 g (0.1 mol) of sodium hydride, 20.63 g (0.1 mol) of 2,6-di-tert-butylphenol, and 26.54 g (0.1 mol) of N-n-dodecylmaleimide in tert-butyl alcohol. The reaction mixture is concentrated in vacuo and the residue is dissolved in 800 ml of toluene. The toluene solution is extracted sequentially with 1M sodium hydroxide (2×100 ml) and water (6×200 ml). The organic phase is dried over anhydrous sodium sulfate. The solvent is removed in vacuo and the residue purified by flash chromatography (8:2 heptane: ethyl acetate eluent) followed by recrystallization from petroleum ether to give 8.15 g (17%) of a white solid: mp 66°-70° C.

1. concentrationThe reaction mixture is concentrated in vacuo
2. dissolutionthe residue is dissolved in 800 ml of toluene
3. extractionThe toluene solution is extracted sequentially with 1M sodium hydroxide (2×100 ml) and water (6×200 ml)
4. dry with materialThe organic phase is dried over anhydrous sodium sulfate
5. customThe solvent is removed in vacuo
6. customthe residue purified by flash chromatography (8:2 heptane: ethyl acetate eluent)
7. customfollowed by recrystallization from petroleum ether